What are HMSC-derived exosomes?

HMSC-derived exosomes are nanoscale extracellular vesicles (30–150nm) secreted by human mesenchymal stem cells. They carry a specific biological cargo - growth factors, immunomodulatory microRNA, neurotrophic proteins, and angiogenic mediators - that reflects the regenerative and anti-inflammatory properties of the source cell. Unlike whole-cell therapies, exosomes deliver this cargo without transferring genetic material or living cells.

What makes ExoPearls™ different from lyophilised exosome powders?

ExoPearls™ are produced via a patented cryo-sphere formation process: purified HMSC exosomes are dropped into liquid nitrogen at a controlled rate, forming solid 3–4mm spheres that lock biological cargo in a stable amorphous matrix without freeze-drying stress. ExoPearls™ preserve native vesicle architecture, reconstitute instantly on contact with saline with no aggregation risk, and are verified for biological activity across a 12-month ambient shelf life - with zero cryoprotectant additives in the final product.

What documentation is provided with each order?

Every BEXO shipment includes a full Certificate of Analysis (COA) with batch-level traceability covering: NTA particle analysis, TEM morphological confirmation, ELISA tetraspanin panel (CD9, CD63, CD81), RNA sequencing, 14-pathogen viral screen, USP sterility, and LAL endotoxin assay (<0.1 EU/mL).

Who can purchase BEXO biologics?

BEXO biologics are supplied exclusively to licensed medical practitioners, verified research institutions, and registered clinics. Credentials are verified within 48 hours of application. Individual patients access BEXO biologics through a Partner Practitioner in their region.

Are ExoPearls™ FDA approved?

ExoPearls™ are investigational research-grade biologics and are not approved therapeutic products by the FDA, EMA, or any other regulatory authority. Supply in the United States is limited to research use only. Practitioners assume full clinical and regulatory responsibility for patient administration.

What is the shelf life and how do ExoPearls™ ship?

ExoPearls™ maintain verified biological activity at ambient temperature for 12 months. No cold chain required. BEXO ships worldwide via standard international courier from Hong Kong SAR.

What is the minimum order quantity?

BEXO operates with no minimum order quantity. Volume discounts are available. Wholesale pricing is issued to approved practitioners on account activation.

Raw Biologic Ingredient

HMSC ExoPearls™
Biologics

Q: Who can purchase BEXO biologics?

BEXO biologics are supplied exclusively to licensed medical practitioners, verified research institutions, and registered clinics. Credentials are verified within 48 hours of application. Individual patients access BEXO biologics through a Partner Practitioner in their region.

Q: Are ExoPearls™ FDA approved?

ExoPearls™ are investigational research-grade biologics and are not approved therapeutic products by the FDA, EMA, or any other regulatory authority. Supply in the United States is limited to research use only. Practitioners assume full clinical and regulatory responsibility for patient administration.

Q: What is the shelf life and how do ExoPearls™ ship?

ExoPearls™ maintain verified biological activity at ambient temperature for 12 months. No cold chain required. BEXO ships worldwide via standard international courier from Hong Kong SAR.

Q: What is the minimum order quantity?

BEXO operates with no minimum order quantity. Volume discounts are available. Wholesale pricing is issued to approved practitioners on account activation.

Pharmaceutical-grade human mesenchymal stem cell-derived exosomes in a proprietary cryo-formed sphere format. ExoPearls™ are the world's first exosome biologic produced as a precision-formed solid sphere - not lyophilised powder. Instant dissolution in saline. Supplied to licensed practitioners and research institutions worldwide.

Exosomes are nanoscale vesicles secreted by stem cells - the signalling particles that direct tissue repair, immune modulation, and cellular regeneration.

Request Wholesale Pricing View Specifications

10B+ Exosomes / pearl

12mo Ambient shelf life

GMP Certified source

HK Incorporated

Active Batch · BX-241

HMSC ExoPearls™
2-Sphere Vial

BEXO ExoPearls™ cryo-formed exosome vial - 2-sphere format with ambient stability

Each sphere: ≥ 10 billion exosomes · Ambient stable

SourceVerified donor HMSC · Wharton's Jelly

Concentration≥ 10 billion exosomes / sphere

ReconstitutionInstant dissolution in saline

StorageAmbient temperature · 12 months

SterilityUSP <71> confirmed per batch

Endotoxin< 0.1 EU/mL post-reconstitution

RegistrationBEXO Ltd · Hong Kong SAR

GMP Certified Source USP <71> Sterility Confirmed Xeno-Free Ambient Stable · 12 Months HK Incorporated

Molecular Cargo · Confirmed per batch

HMSC Exosome
Biological Profile

CD9 · CD63 · CD81 tetraspanins - surface identity confirmed
Growth factors: EGF, FGF, VEGF, IGF-1, TGF-β
Anti-inflammatory miRNA: miR-21 · miR-146a
Neuroprotective cargo: BDNF · GDNF signalling molecules
Wnt pathway modulators - follicular regeneration
Immunomodulatory factors: IL-10 · TSG-6 pathway
Angiogenic mediators - tissue vascularisation
Extracellular matrix repair proteins

ExoPearl™ Technology

Cryo-formed spheres -
a distinct format.

Purified HMSC exosomes cryo-formed into solid spheres via a patented cryo-forming process developed by our manufacturing partner - preserving native vesicle architecture within a structured crystalline matrix. Instant dissolution in saline. Zero cryoprotectant additives. 12-month ambient shelf life.

Explore the ExoPearl™ format →

"Systemic administration of MSC-derived exosomes promotes neuroplasticity and neurological functional recovery. The microRNA cargo within exosomes is largely responsible for these therapeutic effects."

Frontiers in Cellular Neuroscience, 2024 - reviewing preclinical TBI and stroke models

Clinical Applications

Four emerging
protocols.

BEXO biologics are supplied to practitioners across four high-interest regenerative medicine indications, each supported by independent peer-reviewed evidence.

Systemic

IV Wellness & Longevity

Intravenous administration for regenerative wellness, anti-ageing, and immune modulation. For physician-supervised clinical use.

Dermatological

Hair Follicle Regeneration

Non-surgical alopecia protocols for dermatologists and trichologists. Among the most studied biologics for follicular regeneration.

Neurological

Neurorecovery & Nerve Repair

For neurologists and rehabilitation specialists in post-stroke recovery, TBI, and peripheral nerve repair.

Pain Management

Chronic Pain & Joint Restoration

For pain specialists and orthopaedic physicians targeting chronic musculoskeletal pain and osteoarthritis.

View full protocol details →

Product Catalogue

Three
formulations.

All BEXO products share the same ExoPearl™ core technology and quality standard, differentiated by concentration and clinical application.

Research / Cosmetic Grade

BEXO·CORE

Open access

2-sphere vial. ≥ 20 billion exosomes. Topical, intradermal, and scalp applications for dermatology and aesthetic practice.

Clinical Protocol Grade

BEXO·PRIME

Licensed practitioners

20-sphere vial. ≥ 200 billion exosomes. IV administration for longevity and regenerative medicine practices.

Neurological Specialist

BEXO·NEURO

Specialist access

3-sphere vial. ≥ 30 billion exosomes. Enriched neuroprotective cargo for stroke recovery, TBI, and nerve repair.

View full specifications & compare →

Scientific Foundation

Peer-reviewed
evidence.

The applications supported by BEXO biologics are grounded in independent published research.

30.8%

Absolute risk reduction in ARDS mortality

CHEST 2023 - Phase 2 RCT

0.7%

SAE rate across all EV clinical trials

NIH Meta-Analysis 2024

9.5–35

Hairs/cm² density gain in alopecia

PMC Systematic Review 2025

CHEST Journal, 2023 - Phase 2 double-blind RCT

BM-MSC-derived EVs: 30.8% absolute risk reduction in ARDS 60-day mortality · Zero treatment-related adverse events (n=102)

PMC Systematic Review, 2025 - 11 clinical studies, 2 RCTs

MSC exosomes: 9.5–35 hairs/cm² density gain; up to 13µm thickness improvement across alopecia types

View all references & QC panel →

Access & Markets

Practitioner supply
& global reach.

BEXO operates a dual-access model - direct supply for licensed practitioners, and a practitioner-mediated pathway for individuals. Incorporated in Hong Kong SAR, shipping worldwide at ambient temperature via standard courier.

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Headquarters

Hong Kong SAR

Common law · Zero import duty · APAC gateway

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Europe

Europe & Western Balkans

Research-grade and cosmetic-grade supply

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Worldwide

Global Distribution

Standard courier · 12-month shelf life · Any destination

Learn about access pathways & all markets →

Professional Account Application

Request access to BEXO biologics.

Licensed practitioners and verified research institutions are invited to apply for a wholesale account. Approval within 48 hours.

Wholesale PricingNo minimum order quantity. Volume discounts available.

Certificate of AnalysisFull COA with every shipment. Batch-level traceability.

Protocol & Reference PackPeer-reviewed guides and formulation documentation.

Dedicated Account SupportPersonal account manager for every partner.

Worldwide DeliveryStandard courier shipping. Room-temp stable.

BEXO ExoPearls™ are investigational research-grade biologics. Not approved therapeutic products. Supplied exclusively to licensed practitioners and research institutions under applicable local regulations.

Account Application

Personal Details

First Name

Last Name

Professional Email

Practice Information

Medical Licence / Registration

Institution / Clinic

Country of Practice

Primary Application

I agree to the processing of my personal data as described in the Privacy Policy. Data is used solely for application review and account management.

Applications reviewed within 48 hours. Credentials verified before activation.

For individual access enquiries, indicate your region and area of interest - we will connect you with a Partner Practitioner.

HMSC ExoPearls™ Biologics

Cryo-formed spheres - a distinct format.

Four emerging protocols.